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美容醫學業永續經營下專案價值之研究

為了解決Scala 2023的問題，作者嚴惠慈 這樣論述：

本研究旨在探討美容醫學業追求永續經營下導入Triple Bottom Line (TBL) 模型在社會、經濟、環境三構面中，從經營者角度探討各構面與整體專案價值，嘗試建構永續經營整體價值之一般化數學模型，及考量綜效價值後各構面最適權重比例，以滿足美容醫學業永續經營下專案價值最大化之目標。從社會構面中內部員工職能訓練時間投入成本專案中，探討訓練成本對醫療糾紛下嘗試導入訓練時間投入成本價值之數學模型，所產生社會構面專案價值進行評估。在經濟構面的廣告行銷專案中，探討經營者在面對不確定美容醫學業環境下廣告預算費用分配的最適投入比例及路徑，以建構廣告預算分配專案價值。此外，探討美容醫學業追求綠色成本投

資其環境構面專案價值，利用非線性收益-成本效用函數關係之風險趨避態度，建構最適決策評估模型。最後，本研究從美容醫學業永續經營綜效價值，導入外在環境在樂觀/正常/悲觀條件下，嘗試評估社會、經濟、環境構面最適權重比例，找出美容醫學業永續經營下整體最適專案價值。研究結果提供在美容醫學業永續經營下面臨外在環境不確定時，有助於該行業考量經營風險並提高美容醫學產業擁有的競爭優勢，以增進企業永續經營發展契機的可行性參考。

Mechanism, expression, characterization, and application of anti-opportunistic and multidrug-resistant Staphylococcus spp. antimicrobial peptides derived from Toxocara canis and Anisakis pegreffii

為了解決Scala 2023的問題，作者宋鵬飛 這樣論述：

Antibiotic-resistant in Staphylococcus species increased concern due to the numerous mortality and persistent infections worldwide. The effective conventional therapeutic drugs for various bacterial infections are severely limited, necessitating novel antimicrobial agent discovery. Antimicrobial pe

ptides (AMPs) gained increased merits due to broad-spectrum activity against microorganisms, modulate host immune response, and low risk of microorganisms developing resistance. In our study, Toxocara canis cuticular extract (Tc-CE) or Anisakis pegreffii somatic extract (Ap-SE) and recombinant prote

ins of T. canis were tested against the antibiotic susceptible and methicillin- and gentamicin-resistant Staphylococcus. The bacteriostatic concentration of Tc-CE for antibiotic susceptible Staphylococcus species was 312.50 μg ml-1 and for the MDRSA was 625.00 μg ml-1. The bactericidal concentration

was twice the bacteriostatic concentration for all the bacteria strains tested. The kill-curve kinetic assay indicated that the antibacterial activity of Tc-CE against the Staphylococcus species was concentration-dependent. Contrary, Ap-SE did not exhibit antibacterial activity against the antibiot

ic susceptible Staphylococcus and MDRSA. Therefore, Ap-SE were excluded from the study. Surrogate Caenorhabditis elegan wild type was used as an animal model to screen anti-infective potential. Tc-CE treatments enhanced various Staphylococcus species infected nematode lifespans and did not affect th

e egg laying or progeny reproduction, indicating protective activity of Tc-CE. Electron micrographs analysis delineated cell wall morphology change and disrupted bacterial cell wall and membrane in the Tc-CE treatments group. In addition, the permeabilization of the propidium iodide increased in the

treated S. aureus, indicating bacterial cell membrane was damage by Tc-CE treatments. The Tc-CE was further analyzed by gel filtration and mass spectrometry to identify that the Uc9 and Uc11 exhibit antibacterial activities. These results elucidated that T. canis proteins exhibited antibacterial ac

tivity against Staphylococcus species, and the proteins identified could be potential candidates of antimicrobial agents and pave the new pathway for future antimicrobial discovery from the parasites.