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Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

為了解決One More Protein的問題，作者 這樣論述：

Eduardo M. da Cruz is the Associate Medical Director of the Heart Institute, Head of the Pediatric Cardiac Critical Care Program and Director of the Cardiac Intensive Care Section and Inpatient Services at Children’s Hospital Colorado, University of Colorado Denver, School of Medicine. He has had an

international life career in Portugal, Costa Rica, France, United Kingdom, Switzerland and the United States of America. He trained in Medicine and then in Pediatrics at the Universidad de Costa Rica and the Hospital Nacional de Niños in San José, Costa Rica, and then pursued a fellowship in pediat

ric cardiology and intensive care in Paris, France (Hôpital Necker-Enfants Malades, Université René Descartes-Paris V- La Sorbonne). After completing his training, Eduardo stayed in Europe as an attending physician until 2007, when he joined the cardiovascular team at Children’s Hospital Colorado in

Denver, USA, where he currently holds the title of Tenured Professor of Pediatrics, Pediatric Cardiology & Intensive Care. He has close to 30 years of experience in the medical and perioperative management of neonates, children and young adults with complex congenital or acquired heart disease, inc

luding heart transplant, mechanical assistance and quality improvement, safety, clinical effectiveness, stewardship, and crew resource management. He is actively involved in clinical and translational research and teaching in the fields of pediatric cardiology and cardiac intensive care, has deliver

ed close to 300 international lectures, and is a reviewer for 28 peer-reviewed journals, and the Editor or Co-Editor of eight CICU textbooks, including the reference entitled Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care (Springer-Verlag UK), a major textbook and e-book/e-r

eference with 6 volumes and close to 4000 pages (Editor-in-Chief) and the first Textbook dedicated to the Intensive Care of Adults with Congenital Heart Disease (Editor-in-Chief). He has published 80 book chapters and more than 100 manuscripts in peer-reviewed journals. He is the Emeritus Founder of

the Working Group on Pediatric Cardiac Intensive Care of the Association for the European Pediatric and Congenital Cardiology (AEPC), Past-Chair and founder of the Section on Pediatric and Congenital Cardiac Intensive Care & Mechanical Circulatory Support of the European Society of Pediatric and Ne

onatal Intensive Care (ESPNIC), a former Board Member of the Congenital Domain of the European Association for Cardio-Thoracic Surgery (EACTS), member of the Society of Pediatric Research (SPR), the European Society of cardiology (ESC) and of multiple other international Societies. Eduardo da Cruz i

s also an Expert Reviewer for the European Commission Horizon 2020 Project, and the President and Chair of the Board of Surgeons of Hope Foundation, a United Nations-affiliated Non-Governmental Organization based in New York, USA. In 2019, he was the recipient of the American College of Cardiology D

istinguished Service Award.Dr. Dunbar Ivy began his medical career at Tulane University School of Medicine following his premedical studies at Davidson College. While at Tulane, he became excited about a career in Pediatric Cardiology under the mentorship of Dr Arthur Pickoff. He then obtained train

ing in General Pediatrics at the University of Colorado School of Medicine in Denver, Colorado. Early mentors in Pediatric Cardiology included Drs. Michael Schaffer and Henry Sondheimer. Interest in altitude related illness and pulmonary hypertension in congenital heart disease were fostered by Dr R

obert Wolfe on the clinical side and Drs Steve Abman and John Kinsella in the fetal sheep laboratory while a fellow in Pediatric Cardiology at the University of Colorado. Following fellowship, he became a research instructor under the guidance of Dr Mark Boucek, who encouraged him to pursue a career

as a clinician scientist. During his time as a Bugher fellow, he obtained early grants from the March of Dimes and American Heart Association regarding the role of endothelin in the perinatal pulmonary circulation. This work transitioned into a National Institutes of Health K-08 award to continue t

o study molecular derangements in the endothelin pathway in models of pulmonary hypertension. In 2003 Dr Ivy took the position of Chief of Pediatric Cardiology and Selby’s Chair of Pediatric Cardiology. His research focus became more clinical and translational. As Director of the Pediatric Pulmonary

Hypertension Program, he began early clinical studies of medical therapy in children, including the use of intravenous epoprostenol, subcutaneous treprostinil, and oral bosentan. He began to work with Dr Robin Shandas regarding measurement of right ventricular afterload in children with pulmonary h

ypertension in an NIH sponsored Specialized Centers of Clinically Oriented Research grant headed by Dr Kurt Stenmark. Further work on ventricular vascular coupling has continued with NIH funding. Dr Ivy was the inaugural Chairman of the first Pediatric Pulmonary Hypertension taskforce at the World S

ymposium of Pulmonary Hypertension in Nice, France in 2013. Dr. Ivy is a member of multiple societies, and has published over 250 peer reviewed manuscripts.Dr. James Jaggers was born and raised in Western Nebraska. He completed medical school at the University of Nebraska Medical Center in Omaha Neb

raska. He then completed General Surgery at the Oregon Health Sciences University in Portland Oregon and Thoracic Surgery training at the University of Colorado Health Sciences Center in Denver, where he also completed a Pediatric Cardiac Surgery Fellowship at The Childrens Hospital In Denver. From

there, his first Faculty position was as assistant professor of Surgery at Duke University Medical Center where he rose to the rank of Associate Professor with tenure and Chief of Pediatric Cardiac Surgery and Director of the Duke Pediatric Heart Institute. During his time as chief of Pediatric Card

iac Surgery at Duke, Dr. Jaggers directed the pediatric cardiovascular surgery laboratory and mentored many research fellows. He was principal and co-principal investigator on two basic Science NIH grants and one Pediatric Heart Network NHLBI sponsored multicenter study. In 2010, Dr. Jaggers moved t

o the University of Colorado and Children’s Hospital Colorado where he is now the Barton Elliman Chair of Congenital Cardiac Surgery and Professor of Surgery. Dr. Jaggers’s Clinical focus is in all areas of Congenital Cardiac Surgery including complex neonatal repairs, single ventricle surgery, hear

t transplantation and surgery for connective tissue disorders. He has special interest in quality, safety and effective care for children. He is also the program director for the University of Colorado’s Congenital cardiac surgery training program. His research interests include Stem cell delivery t

o improve heart function in children with complex congenital heart disease, and laboratory research in investigation into the protein signaling of aortic stenosis and uncompensated cardiac hypertrophy and myocardial dysfunction. Dr. Jaggers is a member of multiple Societies, and has published over 1

40 peer reviewed manuscripts, published 30 book chapters and is a reputed national and international educator and lecturer.

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運動訓練與停止訓練對中老年人骨骼肌氧合能力與身體功能表現之影響

為了解決One More Protein的問題，作者杨永 這樣論述：

運動是一種改善中老年人骨骼肌氧合能力、提高肌肉力量並最終影響整體身體功能表現的有效方式。然而，較少的研究評估不同運動類型之間訓練效益的差異。此外，由於中老年人生病、外出旅行與照顧兒童等原因，迫使運動鍛煉的中斷。如何合理安排運動訓練的週期、強度與停訓週期，以促使中老年人在未來再訓練快速恢復以往訓練效益，目前亦尚不清楚。本文以三個研究建構而成。研究I：不同運動訓練模式對中老年人的骨骼肌氧合能力、肌力與身體功能表現的影響。以此探討50歲及以上中老年人進行每週2次為期8週的爆發力、阻力訓練以及心肺訓練在改善中老年人肌肉組織氧合能力、與肌肉力量身體功能效益的差異。我們的研究結果表明：爆發力組在改善下肢

肌力、最大爆發力與肌肉品質方面表現出較佳的效果。心肺組提高了30s坐站測試成績並減少了肌肉耗氧量，從而改善了中老年人在30s坐站測試期間的運動經濟性。年紀較高的肌力組則對於改善平衡能力更加有效。此外，三組運動形式均有效改善了中老年人人敏捷性。研究 Ⅱ：停止訓練對運動訓練後中老年人肌力與身體功能表現的影響：系統性回顧與meta分析。本研究欲探討停止訓練對運動訓練後中老年人肌力與身體功能表現訓練效益維持的影響。我們的研究結果表明：訓練期大於停止運動訓練期是肌力維持的重要因素。若訓練期

You Should Smile More: How to Dismantle Gender Bias in the Workplace

為了解決One More Protein的問題，作者Hudson, Dawn,Nicholson, Cie,Short, Mitzi 這樣論述：

You Should Smile More: How to Dismantle Gender Bias in the Workplace empowers women and men to unlock a culture of greatness in the workforce--one little thing at a time. Written by six C-suite women with a collective resume covering 29 industries, the book offers a completely new lens through which

to talk about and tackle the stubborn remnants of gender bias at work.＂In the business world, barriers to inclusion are barriers to success,＂ states a line from the book’s Introduction. ＂Diversity breeds better solutions faster if people feel comfortable in their environment.＂ But from small indign

ities to unconscious slights, women experience situations at work every day that may seem small or unimportant but that effectively differentiate and exclude them. These are not #MeToo moments - they are micro-offenses; the small, awkward, or uncomfortable moments that slow-build until the unwelcome

environment takes hold and women disengage. Situations the authors address range from things like use of the term ＂girl＂ versus ＂woman,＂ watching male colleagues leave work for a social event where women colleagues were left off the invite list or hearing that a qualified woman shouldn’t be offere

d an assignment because she has small children at home. You Should Smile More shows witnesses, allies, supervisors, and women at every level in their careers how to dismantle everyday gender bias, based upon the latest research, personal accounts, and interviews with dozens of professionals, both wo

men and men. Widely known as a meme, the title itself is now a call-to-action against the very advice women so frequently hear from male colleagues or bosses. The authors spotlight these all-too-familiar moments, offering realistic strategies every witness can use to confront and productively addre

ss them. The information within the book finally advances women in the corporate workplace as equals and advances organizations on the path to creating cultures of true inclusion. The authors call themselves ＂The Band of Sisters＂ and have collectively seen it all, from the bottom rung to the boardr

oom. They know firsthand how hard it is to navigate these gendered situations in the moment. Now they share their experience with a forward-looking eye -- often with humor, and in a way that recognizes the realities of the workplace. With this book as a guide, The Band of Sisters are ready to: + H

elp anyone to recognize and effectively respond to these micro-moments rooted in gender bias. + Pave the way for their ultimate elimination, through shared participation. + Allow organizations to build high-performance cultures that truly value and include diverse perspectives and experiences. Ge

nder bias has been part of our workplaces for too long. We are at the point now where all of us who are in the workplace, around conference tables, water coolers and in Zoom meetings, must make the next push for real change. Dawn Hudson is a senior executive and keynote speaker. She is a founding

member of ＂The Band of Sisters＂ after spending 11 years at PepsiCo as CMO, then President and CEO of Pepsi-Cola North America. After PepsiCo, she served as Vice-Chairman of Parthenon (now part of EY). Later she was the CMO of the NFL responsible for development of the fan base, the brand, and overse

eing all NFL produced events including the Super Bowl. Dawn also has significant governance experience having served on boards of directors of Lowe’s Home Improvement Stores, Allergan Pharmaceutical, PF Changs, and Amplify (sold to Hershey’s). She served as Chairperson of the LPGA (Ladies Profession

al Golf Association) and ANA (Association of National Advertisers). She currently serves on the boards of Nvidia, Interpublic Companies, and Rodan + Fields. Dawn earned her MBA at Dartmouth College. She is passionate about the difference a good culture can make on sustained performance. She is equal

ly passionate about staying competitive in tennis, paddle tennis and golf against increasingly younger players. Cie Nicholson is an investor, and advisor to a number of start-up companies, a speaker, and a founding member of ＂The ＂Band of Sisters＂ after spending 11 years at PepsiCo in marketing posi

tions, including Chief Marketing Officer, Pepsi-Cola N.A. After PepsiCo, she served as EVP and CMO of Equinox, SVP and CMO of Softcard (fintech start-up acquired by Google). She presently serves as public board director for Selective Insurance and served as a private board member for Heartland Food

Group and the ANA (Association of National Advertisers). Cie earned her BS at the University of Illinois and her MBA at Indiana University. Cie lives in NYC however she is on a 20-year quest (2015-2035) to do handstands all over the world - Instagram @cienicholson Mitzi Short, an executive coach and

speaker, is the Co-Founder and CEO of New Season Coaching & Consulting Group, and a founding member of ＂The Band of Sisters,＂ after spending 25 years at PepsiCo in sales, operations, and marketing leadership roles, including PepsiCo Customer Team VP/GM and VP of Multicultural Marketing. Mitzi also

serves as an Adjunct Executive Coach for the Center for Creative Leadership and for the University of Oregon’s Executive MBA Program. She is a Fund for Education Abroad Board Member and former member of Davidson College’s Board of Trustees, The Executive Leadership Council, and GOLFTEC’s Franchise A

dvisory Board Mitzi earned her Bachelor of Arts in Economics from Davidson College and M.B.A. from the University of Oregon. Mitzi is a big sports fan who loves traveling, playing golf, and spending time with family and friends. In addition, she is a GOLFTEC Franchise Owner and contributing author o

f Teeing Up for Success. Katie Lacey is a former CEO and General Manager, a speaker, and a founding member of ＂The ＂Band of Sisters＂ after spending 12 years at PepsiCo in a variety of marketing roles at both Frito-Lay and Pepsi Cola. After leaving PepsiCo she served as SVP, Marketing for ESPN. She m

ost recently served as President & CEO of Crane Stationery, where she led a turnaround of the iconic 200-year-old business and the successful sale of the company. Katie earned her Bachelor of Arts from the University of Virginia and an M.B.A. from Northwestern University’s Kellogg School of Manageme

nt. Presently, Katie lives in NYC where she serves as a Board member of wellness brand, Designer Protein. Lori Tauber Marcus is a corporate board director, executive coach, and founding member of ＂The ＂Band of Sisters＂ after spending 24 years at PepsiCo in multiple roles, including Senior Vice Presi

dent, Marketing Activation. After PepsiCo, she served as SVP, CMO of The Children’s Place Retail Stores, EVP, Chief Global Brand & Product Officer at Keurig Green Mountain, and Interim Global CMO, Peloton Interactive. She also served for several years as the leader of the direct-to-patient workstrea

m at Harvard Business School’s Kraft Precision Medicine Accelerator. Lori also has significant Board experience and presently sits on the boards of Fresh Del Monte Produce and 24-Hour Fitness. She earned her BS from the Wharton School of Business at the University of Pennsylvania. Lori lives in Conn

ecticut and is a health and fitness nut. You can find her most mornings riding her Peloton bike at the crack of dawn. Angelique Bellmer Krembs is the Global Head of Brand at BlackRock and a founding member of ＂The Band of Sisters,＂ after 23 years at PepsiCo, leading turnaround and growth for many be

loved brands, including Pepsi, Mountain Dew, and SoBe, and a variety of cross-divisional leadership roles. After PepsiCo, she was CMO at News America Marketing, a division of News Corp, then created a ＂Fractional CMO＂ practice across a portfolio of startups and emerging brands before joining BlackRo

ck as Global Head of Brand. She earned a Bachelor of Science in Foreign Service from Georgetown University, and an MBA from Dartmouth’s Tuck School of Business. Angelique passionately believes in ＂performance with purpose,＂ and that great business results and high functioning teams always ＂start wit

h why.＂

潛藏危機：Musashi-1固有無序區域介導與神經退行性疾病相關蛋白之異常聚集

為了解決One More Protein的問題，作者杜岱芸 這樣論述：

蛋白質病變(proteopathy)是退行性疾病的常見原因，通過錯誤折疊的蛋白質異常聚集形成類澱粉沉積症(amyloidogenesis)，從而導致破壞組織內的穩態。尤其是，近期研究表明細胞內具有固有無序區域 (intrinsically disordered regions)的蛋白容易進行液-液相分離(liquid-liquid phase separation)，從而在細胞中組裝蛋白質凝聚層(coacervates)。在本研究中，我們假設具有固有無序區域的蛋白質受環境壓力影響，促進異常折疊甚至形成聚集體，這將進一步形成澱粉樣斑塊(amyloid plaques)並在組織內堆積，導致蛋白質

病變。我們主要探討不僅是RNA結合蛋白、也是幹性基因的Musashi-1，是否與具有豐富IDR的Musashi-1 C-末端區域相互作用以進行液-液相分離，最終形成澱粉樣原纖維(amyloid fibrils)。為了確認哪些序列更易於形成澱粉樣蛋白，因此對Musashi-1的C-末端進行了序列連續刪除來取得不同長度的片段。我們的研究結果表明Musashi-1 C-末端面對不同pH值和鹽濃度會影響液-液相分離狀態，包含改變蛋白質相分離的出現時間、形狀和大小，隨著時間的推移，Musashi-1 C-末端也可以形成澱粉樣蛋白原纖維。而當在氧化壓力下，它會在細胞內誘導組裝應激顆粒與不可逆的聚集體的形成

，另一方面，當細胞同時表達Musashi-1 C-末端和內源性TDP-43，Musashi-1 C-末端誘導TDP-43從細胞核錯誤定位到細胞質。此外，Musashi-1 C-末端促進磷酸化和泛素化TDP-43。總結來說，我們提出了關於Musashi-1與神經退行性疾病相關蛋白相互作用導致異常聚集的新見解，這些發現有助於提供解決退行性疾病的新思路。