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台灣中老年人飲食模式與腎臟功能障礙之關聯：2008年至2010年的橫斷研究

為了解決CX 5 2023 PTT的問題，作者盧卡思 這樣論述：

Objective: Chronic Kidney Disease (CKD), characterized by impaired kidney function, affects over 1.5 million individuals in Taiwan. Low testosterone levels, cardiovascular disease (CVD), dyslipidemia, anemia, and low-grade inflammation are commonly found in impaired kidney function CKD subjects. Si

nce diet plays an important role in the development of the outcomes of CKD aforementioned, our study was designed to investigate the association of dietary patterns with testosterone levels, cardiovascular risk factors, dyslipidemia, anemia, and the severity of impaired kidney function in middle-age

d and older adults in Taiwan.Methods: 41,128 participants aged more than 40 years old with an estimated glomerular filtration rate (eGFR) less than 90 mL/min/1.73 m2 and positive urinary protein were recruited from Mei Jau Health Institute between 2008 and 2010. The dietary patterns were identified

using principal component analysis (PCA) and reduced rank regression (RRR) method was used to determine the kidney function-, inflammatory-, and metabolic syndrome (MetS) - related dietary pattern. A multivariable linear regression analysis was used to identify the association between dietary patter

ns derived by PCA with testosterone levels and kidney function biomarkers. While, a multivariable logistic regression analysis was used to identify the association between dietary pattern derived by RRR with the severity of impaired kidney function, cardiovascular risk factors, dyslipidemia, anemia,

and MetS components.Results: Males with higher tertile of fried-processed dietary pattern score was associated with decreased testosterone levels by 0.8 nmol/L (95% CI: -1.40, -0.16), reduced testosterone-to-TG (T/TG) ratio by 1.8 units (95% CI: -2.99, -0.53), and increased risk of moderate/severe

decline in kidney function (eGFR < 60 mL/min/1.73 m2) by 1.35 (95% CI: 1.15, 1.58). The kidney function-related dietary pattern characterized by frequent intakes of preserved or processed food, meats and organ meats, rice and flour products, and low intakes of fruit, dark-colored vegetables, bread,

and legumes or beans. In both genders, high adherence of dietary score was correlated with 2.07 times (95% CI 1.89–2.27) risk of obese weight status, 10 to 31% risk of cardiovascular risk, and 1.15 times (95% CI 1.02–1.29) risk of moderately or severely impaired kidney function. The higher adherence

of inflammatory dietary pattern (low intakes of seafood, grains, vegetables, and fruit but frequent intakes of meats, eggs, preserved or processed food, and sweet drinks) was associated with increased 21% risk of dyslipidemia in males and increased 35% - 47% risk of anemia in both genders. There wa

s an association between high consumption of inflammatory dietary pattern with reducing eGFR (males and females; β = -0.85 and -0.53, p < 0.05 respectively) and increased CRP level and/or neutrophil-to-lymphocyte (N/L) ratio in both genders. Moreover, compared with PCA method, RRR shows stronger sta

tistical associations with MetS.Conclusion: Our findings suggest that high intakes of processed and animal foods and low intake of seafood and plant foods predict the risk for developing hypogonadism, cardiovascular disease, dyslipidemia, anemia, and rapid kidney function decline.