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L-半胱胺酸在體內和體外實驗對順鉑引起男性生殖之損傷影響

為了解決ARÖD 工作燈的問題，作者陳儀滋 這樣論述：

臨床常見治療癌症之化療藥物Cisplatin (CIS)造成睪丸功能障礙之副作用會影響男性生殖功能。睪丸內細胞因氧化壓力增加會促使發炎反應，細胞走向凋亡損傷，亦會發生精子生成異常，最終造成睪丸功能性受損。而L-半胱胺酸 (L-cysteine, CYS)因具有強大抗氧化、抗發炎等功效，但至今對男性生殖影響之相關機制研究尚未明確證實，故本研究目的為考慮臨床輔助治療之應用，以體內及體外模式探討CYS對CIS造成男性生殖損傷之相關改善效應。體外實驗利用TM3及TM4小鼠睪丸細胞株，以MTS試驗及結晶紫染色測定細胞存活率，以Western blot測定血睪障壁、發炎及細胞凋亡相關蛋白表現。結果顯示，

CYS可顯著恢復CIS誘導TM3及TM4細胞存活率，並減少Caspase3、PARP、Bax凋亡相關蛋白表現，同時降低TM3細胞NLRP3及COX2發炎相關蛋白表現，且增加TM4細胞ZO-1結構蛋白表現。亦以CIS建立誘導睪丸損傷之動物模式，實驗期21天後，發現CYS可顯著降低睪丸組織及精子結構損傷，維持血清睪固酮濃度，恢復精子存活狀態，並且減少睪丸PARP蛋白表現。因此，本研究表明L-cysteine可改善Cisplatin對男性生殖之不利影響，顯示L-cysteine具有輔助臨床Cisplatin藥物治療下對男性生殖功能損傷之保護潛力。

Prevalence and factors associated with Suicidal Behaviour in Eswatini

為了解決ARÖD 工作燈的問題，作者MOTSA MFUNDI PRESIDENT SEBENELE 這樣論述：

AbstractIntroductionThe determinants of suicidal behaviour are not well understood for both adolescents and the general adult population in Eswatini. The problem of SB is a lifetime experience that can affect anyone, both young and old. Hence, the research was performed to generate evidence on the

factors associated with suicidal behavior in the aforementioned populations. This dissertation contains two studies. The first study employed a mediation approach to evaluate the roles of multiple mediators (anxiety and loneliness) in the relationship of food insecurity (FI) and being bullied (BB) o

n suicidal behavior (SB) among adolescents in schools. Additionally, it used analysis approaches to assess the combined roles of food insecurity and being bullied on SB, anxiety, and loneliness. The second study addressed whether chronic disease and lifestyle are associated with suicidal ideation (S

I) among adults in Eswatini. Moreover, the study examined the potential modification roles of socioeconomic status (SES) on the association of chronic diseases and lifestyle factors with SI.MethodsStudy hypotheses were examined through secondary analysis from the Global School-based Health Survey (G

SHS) 2012 and STEPwise Approach to NCD Risk Factor Surveillance Survey (STEPS) 2013 surveys. Both of these surveys were designed to produce nationally representative samples using stratified sampling approaches. For our analysis (study 1), we included 3,264 students aged 13-17 years, who responded t

o the questions on food insecurity, being bullied, loneliness, anxiety, and SB. Data for the primary survey were collected through self-administered questionnaires, which were executed through regular class periods. We employed bivariate and multivariate regression models to estimate factors associa

ted between FI and BB with SB, anxiety and loneliness. In addition, we used a binary mediation regression model to assess the potential mediation roles of anxiety and loneliness on the association between FI and BB with SB. The second study utilized STEPs and used a complex sampling design, where a

total of 216 primary sampling units (PSU) were selected using probability-proportionate-to-size sampling. About 20 households were systematically sampled from the PSU to form secondary sampling units. Our analysis, included 3026 adult men and women aged 18 - 69 years who gave responses to the questi

ons on suicide to ascertain the presence or absence of suicidal thoughts. Bivariate and multivariate logistic regression models were used to estimate the associated factors between chronic disease and lifestyle factors with SI.ResultsStudy 1: The results demonstrated that SB, anxiety, and loneliness

were more likely for adolescents who had combined food insecurity and being bullied; were being bullied only; were food insecure only; were physically attacked; had a fight; had no friends; were truant; used marijuana and lacked parental support (all p