2018 ES200的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列各種有用的問答集和懶人包

Speech Sound Disorders in Children: Articulation and Phonological Disorders

為了解決2018 ES200的問題，作者Bernthal, John E.,Bankson, Nicholas W.,Flipsen, Peter 這樣論述：

John Bernthal, Ph.D., is an Emeritus Professor at University of Nebraska-Lincoln. His career included positions in the public schools of Louisiana, at the Northwestern State (Louisiana), Minnesota State University-Mankato, University of Maryland, University of Northern Iowa and University of Nebras

ka-Lincoln. He served for 30 years as a department chair at the latter two institutions. He has published articles, tests, and books in the areas of speech sound disorders in children. He has received the Honors of the American Speech-Language-Hearing Association, the Council of Academic Programs in

Communication Sciences and Disorders, the National Student Speech-Language and Hearing Association, named 2007 Kansas University Distinguished Allied Health Alumnus, and served as President of the American Speech Language and Hearing Association.Nicholas Bankson, Ph.D., is an Emeritus Professor at

James Madison University. His career included tenured positions at the University of Maryland, Boston University, and James Madison University. Dr. Bankson served for 27 years as a department chair that included the latter two institutions. He has published articles, tests, and books in the areas o

f speech sound disorders in children, and child language disorders. He has received the Honors of the American Speech-Language-Hearing Association, the Council of Academic Programs in Communication Sciences and Disorders, and the National Student Speech-Language and Hearing Association.Peter Flipsen

Jr., Ph.D., S-LP(C), CCC-SLP, is a Professor of Speech-Language Pathology at Pacific University. Dr. Flipsen has more than 30 years of experience in the field as a clinician, teacher, and researcher. He teaches courses in phonetics, speech sound disorders in children, and research methods. He has

published more than 30 peer-reviewed journal articles in the field. His research has focused on classification of speech sound disorders, measurement of intelligibility of speech, speech and language development in children with cochlear implants, and the treatment of residual speech errors in older

children.Leah Fabiano-Smith, Ph.D., CCC-SLP is an Associate Professor and Director of the Multicultural and Bilingual Certificate Program at the University of Arizona. Her research interests focus on phonological acquisition and disorders in bilingual Spanish-English-speaking children and health di

sparities for the Latinx community due to misdiagnosis of disorder.Gail T. Gillon, Ph.D. is Director of the Child Well-being Research Institute at the University of Canterbury, New Zealand, and is Co-director of A Better Start National Science Challenge, a 10-year program of research focused on ens

uring all children’s learning success and well- being. She has an extensive publication record in children’s speech-language and literacy development. Brian A. Goldstein, Ph.D., CCC-SLP, is Chief Academic Officer and Executive Dean of the College of Rehabilitative Sciences Health Sciences at Univer

sity of St. Augustine for Health Sciences in San Marcos, California. He holds a B.A. in linguistics and cognitive science from Brandeis University and an M.A. and Ph.D. in speech-language pathology from Temple University. Dr. Goldstein is well-published in the area of communication development and d

isorders in Latino children. His focus is on phonological development and disorders in monolingual Spanish-speaking and Spanish-English bilingual children. He is a fellow of the American Speech-Language-Hearing Association (ASHA) and received ASHA’s Certificate of Recognition for Special Contributio

n in Multicultural Affairs.Aquiles Iglesias, Ph.D., focuses on language development and assessment of Bilingual (Spanish/English) children. He is the author of the Bilingual/English Spanish Assessment (BESA), Systematic Analysis of Language Transcripts (SALT), the Quick Interactive Language Screener

(QUILS), and the Quick Interactive Language Screener: English/Spanish (QUILS: ES).Laura M. Justice, Ph.D., is Distinguished Professor of Educational Psychology at The Ohio State University. Dr. Justice is also Executive Director of the Crane Center for Early Childhood Research and Policy as well as

the Schoenbaum Family Center. A certified speech-language pathologist, much of her research focuses on identifying strategies to improve the language skills of young children, including those with disabilities.Raymond D. Kent, Ph.D.is Professor Emeritus of the Department of Communication Sciences a

nd Disorders, University of Wisconsin-Madison. Dr. Kent’s primary research interests are (1) speech intelligibility in various clinical populations, especially motor speech disorders in children and adults, (2) typical and atypical development of speech in children, and (3) the development and refin

ement of methods for the study of speech and its disorders. Most recently, he collaborated on a NIH-supported project that uses MR and CT imaging along with acoustic analyses to study the anatomic development of the vocal tract in relation to its acoustic properties. Dr. Kent has published several s

pecialty books and is currently working on a dictionary of communication sciences and disorders.Sharynne McLeod, Ph.D. is a speech-language pathologist and professor of speech and language acquisition at Charles Sturt University, Australia. She is an elected Fellow of the American Speech-Language-He

aring Association and Life Member of Speech Pathology Australia. She was named Australia’s Research Field Leader in Audiology, Speech and Language Pathology (2018, 2019, 2020) and has won Editors’ Awards from Journal of Speech, Language, and Hearing: Speech (2018) and American Journal of Speech-Lang

uage Pathology (2019). She was an Australian Research Council Future Fellow, previous editor-in-chief of the International Journal of Speech-Language Pathology, and has coauthored 11 books and over 200 peer-reviewed journal articles and chapters focusing on children’s speech acquisition, speech soun

d disorders, and multilingualism.Brigid C. McNeill, Ph.D. is a speech-language therapist and Professor and Deputy Head of School of Teacher Education in the College of Education, Health and Human Development at the University of Canterbury. Dr. McNeill is an international expert on literacy developm

ent in children with childhood apraxia of speech. Her research also focuses on developing and evaluating methods to better prepare teachers to support children’s early literacy development. Carol A. Tessel, Ph.D., CCC-SLP is an Associate Professor at Albizu University-Miami Campus. Dr. Tessel has be

en a bilingual speech-language pathologist for 20 years, with clinical specialties in early intervention, bilingualism, and speech sound disorders. Her research includes issues of second language acquisition, bilingual phonology, neurophysiology of speech perception, and pedagogy in communication sc

iences and disorders. She currently teaches courses in disorders of articulation and phonology, evaluation and treatment of culturally and linguistically diverse populations, clinical phonetics, acoustics, and research methods in communication sciences and disorders. â ƒ

2018 ES200進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決2018 ES200的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.